HMM Summary Page: TIGR04096

FunctionDNA phosphorothioation-associated putative methyltransferase
Trusted Cutoff150.00
Domain Trusted Cutoff150.00
Noise Cutoff75.00
Domain Noise Cutoff75.00
Isology Typesubfamily
EC Number2.-.-.-
HMM Length478
AuthorHaft DH
Entry DateDec 5 2010 4:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family show distant local sequence similarity to a number of S-adenosyl-methionine-dependent methyltransferases. The family is identified by Partial Phylogenetic Profiling as closely tied to the DNA phosphorothioation system (dnd), and members are found adjacent to dnd genes in at least 13 species (Streptomyces lividans TK24, Shewanella frigidimarina NCIMB 400, Mycobacterium abscessus ATCC 19977, Nostoc punctiforme PCC 73102, Vibrio fischeri MJ11, etc.). The DNA phosphorothioation enables a novel form of restriction enzyme activity. Most members of this family appear in species with the DNA phosphorothioation system.