| Accession | TIGR03444 |
| Name | EgtA_Cys_ligase |
| Function | ergothioneine biosynthesis glutamate--cysteine ligase EgtA |
| Gene Symbol | egtA |
| Trusted Cutoff | 370.80 |
| Domain Trusted Cutoff | 370.80 |
| Noise Cutoff | 278.85 |
| Domain Noise Cutoff | 278.85 |
| Isology Type | equivalog |
| EC Number | 6.3.2.2 |
| HMM Length | 390 |
| Mainrole Category | Unknown function |
| Subrole Category | Enzymes of unknown specificity |
| Author | Haft DH |
| Entry Date | Jun 27 2007 1:06PM |
| Last Modified | Jun 21 2012 2:17PM |
| Comment | Members of this bacterial protein family, EgtA, resemble the glutamate--cysteine ligase of the two-step pathway for glutathione (GSH) biosynthesis, but instead are involved in the biosynthesis of the histidine-derived thiol, ergothioneine (EGT). Successful in vitro reconstitution of EGT biosynthesis using EgtBCDE and gamma-L-glutamyl-L-cysteine suggests that this enzyme is a bone fide glutamate--cysteine ligase. |
| References | RN [1]
RM PMID:20420449
RT In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
RA Seebeck FP
RL J Am Chem Soc. 2010 May 19;132(19):6632-3. |
| Genome Property | GenProp0752: ergothioneine biosynthesis (HMM) |
