HMM Summary Page: TIGR03284

Functionthymidylate synthase
Gene SymbolthyA
Trusted Cutoff108.35
Domain Trusted Cutoff108.35
Noise Cutoff90.60
Domain Noise Cutoff90.60
Isology Typeequivalog
EC Number2.1.1.45
HMM Length296
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0004799: thymidylate synthase activity molecular_function
GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 22 2007 1:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are thymidylate synthase, an enzyme that produces dTMP from dUMP. In prokaryotes, its gene usually is found close to that for dihydrofolate reductase, and in some systems the two enzymes are found as a fusion protein. This model excludes a set of related proteins (TIGR03283) that appears to replace this family in archaeal methanogens, where tetrahydrofolate is replaced by tetrahydromethanopterin.
References DR HAMAP; MF_00008; 338 of 351