HMM Summary Page: TIGR02727

Function5-formyltetrahydrofolate cyclo-ligase
Trusted Cutoff84.90
Domain Trusted Cutoff84.90
Noise Cutoff50.25
Domain Noise Cutoff50.25
Isology Typeequivalog
EC Number6.3.3.2
HMM Length182
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOne-carbon metabolism
Gene Ontology TermGO:0006730: one-carbon metabolic process biological_process
GO:0030272: 5-formyltetrahydrofolate cyclo-ligase activity molecular_function
AuthorHaft DH
Entry DateDec 9 2005 4:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism.
ReferencesRN [1] RM 16104022 RT Structural and functional characterization of a 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087). RA Chen S, Yakunin AF, Proudfoot M, Kim R, Kim SH. RL Proteins. 2005 Nov 1;61(2):433-43.
Genome PropertyGenProp0482: 6S RNA (eubacterial RNA polymerase regulator) (HMM-CLUST)