| Accession | TIGR02027 |
| Name | rpoA |
| Function | DNA-directed RNA polymerase, alpha subunit |
| Gene Symbol | rpoA |
| Trusted Cutoff | 227.80 |
| Domain Trusted Cutoff | 227.80 |
| Noise Cutoff | 112.40 |
| Domain Noise Cutoff | 112.40 |
| Isology Type | equivalog |
| EC Number | 2.7.7.6 |
| HMM Length | 298 |
| Mainrole Category | Transcription |
| Subrole Category | DNA-dependent RNA polymerase |
| Gene Ontology Term | GO:0000345: cytosolic DNA-directed RNA polymerase complex cellular_component |
| | GO:0003899: DNA-directed RNA polymerase activity molecular_function |
| | GO:0006350: transcription biological_process |
| Author | Haft DH, Dodson RJ |
| Entry Date | Oct 17 2003 1:43PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family consists of the bacterial (and chloroplast) DNA-directed RNA polymerase alpha subunit, encoded by the rpoA gene. The RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The amino terminal domain is involved in dimerizing and assembling the other RNA polymerase subunits into a transcriptionally active enzyme. The carboxy-terminal domain contains determinants for interaction with DNA and with transcriptional activator proteins. |
| References | RN [1]
RM 9657722
RT Structure of the Escherichia coli RNA polymerase alpha subunit amino-terminal domain.
RA Zhang G, Darst SA.
RL Science. 1998 Jul 10;281(5374):262-6.
RN [2]
RM 7613089
RT The Escherichia coli RNA polymerase alpha subunit: structure and function.
RA Ebright RH, Busby S.
RL Curr Opin Genet Dev. 1995 Apr;5(2):197-203.
DR HAMAP; MF_00059; 671 of 673 |
| Genome Property | GenProp0262: RNA polymerase, bacterial (HMM) |
| | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
