HMM Summary Page: TIGR01814

Gene SymbolkynU
Trusted Cutoff246.40
Domain Trusted Cutoff246.40
Noise Cutoff111.75
Domain Noise Cutoff111.75
Isology Typeequivalog
EC Number3.7.1.3
HMM Length400
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0019441: tryptophan catabolic process to kynurenine biological_process
GO:0030429: kynureninase activity molecular_function
AuthorHaft DH
Entry DateFeb 3 2003 4:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes kynureninase, a pyridoxal-phosphate enzyme. Kynurinine is a Trp breakdown product and a precursor for NAD. In Chlamydia psittaci, an obligate intracellular pathogen, kynureninase makes anthranilate, a Trp precursor, from kynurenine. This counters the tryptophan hydrolysis that occurs in the host cell in response to the pathogen.
Genome PropertyGenProp0659: tryptophan degradation to anthranilate (HMM)