| Accession | TIGR01444 |
| Name | fkbM_fam |
| Function | methyltransferase, FkbM family |
| Trusted Cutoff | 37.70 |
| Domain Trusted Cutoff | 37.70 |
| Noise Cutoff | 26.30 |
| Domain Noise Cutoff | 26.30 |
| Isology Type | subfamily_domain |
| HMM Length | 143 |
| Author | Haft DH |
| Entry Date | Feb 13 2002 3:17PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548. |
| References | RM 8752344
RT Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
RA Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.
RL J Bacteriol 1996 Sep;178(17):5243-8 |
| Genome Property | GenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST) |
