HMM Summary Page: TIGR01444

Functionmethyltransferase, FkbM family
Trusted Cutoff37.70
Domain Trusted Cutoff37.70
Noise Cutoff26.30
Domain Noise Cutoff26.30
Isology Typesubfamily_domain
HMM Length143
AuthorHaft DH
Entry DateFeb 13 2002 3:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.
ReferencesRM 8752344 RT Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. RA Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR. RL J Bacteriol 1996 Sep;178(17):5243-8
Genome PropertyGenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST)