HMM Summary Page: TIGR00543

Functionisochorismate synthase
Trusted Cutoff224.75
Domain Trusted Cutoff224.75
Noise Cutoff214.35
Domain Noise Cutoff214.35
Isology Typesubfamily
EC Number5.4.4.2
HMM Length349
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0008909: isochorismate synthase activity molecular_function
GO:0009234: menaquinone biosynthetic process biological_process
AuthorSelengut J, Haft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved.
ReferencesA2 hmmalign RM 99013725 RT The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli. RA Dahm C, Muller R, Schulte G, Schmidt K, Leistner E RL Biochim Biophys Acta 1998 Oct 23;1425(2):377-86 AL ClustalW_manual
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)
GenProp1058: 2,3-dihydroxybenzoate biosynthesis (HMM)