HMM Summary Page: TIGR00287

FunctionCRISPR-associated endonuclease Cas1
Gene Symbolcas1
Trusted Cutoff71.70
Domain Trusted Cutoff71.70
Noise Cutoff66.00
Domain Noise Cutoff66.00
Isology Typeequivalog
EC Number3.1.-.-
HMM Length327
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004520: endodeoxyribonuclease activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
GO:0046872: metal ion binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.
ReferencesDR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM 11952905 RT Identification of genes that are associated with DNA repeats in prokaryotes. RA Jansen R, Embden JD, Gaastra W, Schouls LM. RL Mol Microbiol 2002 Mar;43(6):1565-75 RN [3] RM PMID:19523907 RT Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. RA Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA RL Structure. 2009 Jun 10;17(6):904-12. DR PFAM; PF01867 DR INTERPRO; IPR002729
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0313: CRISPR system, I-C/Dvulg subtype (HMM-CLUST)
GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM-CLUST)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)
GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST)
GenProp0318: CRISPR system, III-A/Mtube subtype (HMM-CLUST)
GenProp0469: CRISPR system, Dpsyc subtype (HMM-CLUST)
GenProp0768: CRISPR system, Pging subtype (HMM-CLUST)
GenProp0685: CRISPR system, I-D/Cyano subtype (HMM-CLUST)