HMM Summary Page: TIGR00088
| Accession | TIGR00088 |
| Name | trmD |
| Function | tRNA (guanine(37)-N(1))-methyltransferase |
| Gene Symbol | trmD |
| Trusted Cutoff | 195.00 |
| Domain Trusted Cutoff | 195.00 |
| Noise Cutoff | 29.35 |
| Domain Noise Cutoff | 29.35 |
| Isology Type | equivalog |
| EC Number | 2.1.1.228 |
| HMM Length | 233 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA and rRNA base modification |
| Gene Ontology Term | GO:0006400: tRNA modification biological_process |
| GO:0009019: tRNA (guanine-N1-)-methyltransferase activity molecular_function | |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:10PM |
| Last Modified | Jan 9 2012 12:56PM |
| Comment | This model is specfic for the tRNA modification enzyme tRNA (guanine-N1)-methyltransferase (trmD). This enzyme methylates guanosime-37 in a number of tRNAs.The enzyme's catalytic activity is as follows: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. |
| References | RN [1] RM 6337136 RT Purification and characterization of transfer RNA (guanine-1)methyltransferase from Escherichia coli. RA Hjalmarsson KJ, Bystrom AS, Bjork GR. RL J Biol Chem 1983 Jan 25;258(2):1343-51 RN [2] RM 15060037 RT Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth. RA O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brule H, Petit C, Holmes DJ, Zalacain M, Holmes WM. RL J Bacteriol. 2004 Apr;186(8):2346-54. DR HAMAP; MF_00605; 453 of 462 |