HMM Summary Page: TIGR00088

FunctiontRNA (guanine(37)-N(1))-methyltransferase
Gene SymboltrmD
Trusted Cutoff195.00
Domain Trusted Cutoff195.00
Noise Cutoff29.35
Domain Noise Cutoff29.35
Isology Typeequivalog
EC Number2.1.1.228
HMM Length233
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0006400: tRNA modification biological_process
GO:0009019: tRNA (guanine-N1-)-methyltransferase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedJan 9 2012 12:56PM
CommentThis model is specfic for the tRNA modification enzyme tRNA (guanine-N1)-methyltransferase (trmD). This enzyme methylates guanosime-37 in a number of tRNAs.The enzyme's catalytic activity is as follows: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.
ReferencesRN [1] RM 6337136 RT Purification and characterization of transfer RNA (guanine-1)methyltransferase from Escherichia coli. RA Hjalmarsson KJ, Bystrom AS, Bjork GR. RL J Biol Chem 1983 Jan 25;258(2):1343-51 RN [2] RM 15060037 RT Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth. RA O'Dwyer K, Watts JM, Biswas S, Ambrad J, Barber M, Brule H, Petit C, Holmes DJ, Zalacain M, Holmes WM. RL J Bacteriol. 2004 Apr;186(8):2346-54. DR HAMAP; MF_00605; 453 of 462