HMM Summary Page: TIGR00019

Functionpeptide chain release factor 1
Gene SymbolprfA
Trusted Cutoff423.25
Domain Trusted Cutoff423.25
Noise Cutoff330.00
Domain Noise Cutoff330.00
Isology Typeequivalog
HMM Length361
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003747: translation release factor activity molecular_function
GO:0006415: translational termination biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift.
ReferencesSE TIGR GA hmmsw DR HAMAP; MF_00093; 498 of 505
Genome PropertyGenProp0746: translation termination, bacterial (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)