HMM Summary Page: TIGR04559

Functionquinoprotein relay system zinc metallohydrolase 2
Trusted Cutoff280.00
Domain Trusted Cutoff280.00
Noise Cutoff240.00
Domain Noise Cutoff240.00
Isology Typehypoth_equivalog_domain
EC Number3.-.-.-
HMM Length283
AuthorHaft DH
Entry DateAug 29 2014 1:17PM
Last ModifiedSep 16 2014 4:02PM
CommentBy homology, members are Zn metallohydrolases in the same family as the SoxH protein associated with sulfate metabolism, Bacillus cereus beta-lactamase II (see PDB:1bc2), and, more distantly, hydroxyacylglutathione hydrolase (glyoxalase II). All members occur in genomes with both PQQ biosynthesis and a PQQ-dependent (quinoprotein) dehydrogenase that has a motif of two consecutive Cys residues (see TIGR03075). The Cys-Cys motif is associated with electron transfer by specialized cytochromes such as c551. All these genomes also include a fusion protein (TIGR04557) whose domains resemble SoxY and SoxZ from thiosulfate oxidation. A conserved Cys in this fusion protein aligns to the Cys residue in SoxY that carries sulfur cycle intermediates. In many genomes, the genes for PQQ biosynthesis enzymes, PQQ-dependent enzymes, their associated cytochromes, and members of this family are clustered. Note that one to three closely related Zn metallohydrolases may occur; this family represents a specific clade among them. Some members of this family have a short additional N-terminal domain with four conserved Cys residues.
Genome PropertyGenProp1101: quinoprotein cytochrome relay system (HMM)