HMM Summary Page: TIGR04550

Functionsoluble methane monooxygenase-binding protein MmoD
Gene SymbolmmoD
Trusted Cutoff80.00
Domain Trusted Cutoff80.00
Noise Cutoff28.00
Domain Noise Cutoff28.00
Isology Typeequivalog
HMM Length64
AuthorHaft DH
Entry DateAug 20 2014 2:42PM
Last ModifiedAug 20 2014 2:45PM
CommentMembers of this family are MmoD, a protein that binds the soluble (as opposed to the membrane-bound, copper-rich, particulate) methane monooxygenase and may regulate its activity. Recent work suggests that MmoD, together with methanobactin, acts a copper switch to regulate which enzyme form is produced.
ReferencesRN [1] RM PMID:11709550 RT Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath). RA Merkx M, Lippard SJ RL J Biol Chem. 2002 Feb 22;277(8):5858-65. RN [2] RM PMID:15610020 RT Preparation and X-ray structures of metal-free, dicobalt and dimanganese forms of soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath). RA Sazinsky MH, Merkx M, Cadieux E, Tang S, Lippard SJ RL Biochemistry. 2004 Dec 28;43(51):16263-76. RN [3] RM PMID:23682956 RT Methanobactin and MmoD work in concert to act as the 'copper-switch' in methanotrophs. RA Semrau JD, Jagadevan S, Dispirito AA, Khalifa A, Scanlan J, Bergman BH, Freemeier BC, Baral BS, Bandow NL, Vorobev A, Haft DH, Vuilleumier S, Murrell JC RL Environ Microbiol. 2013 Apr 29. doi: 10.1111/1462-2920.12150.