Comment | Members of this family are MmoD, a protein that binds the soluble (as opposed to the membrane-bound, copper-rich, particulate) methane monooxygenase and may regulate its activity. Recent work suggests that MmoD, together with methanobactin, acts a copper switch to regulate which enzyme form is produced. |
References | RN [1]
RM PMID:11709550
RT Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath).
RA Merkx M, Lippard SJ
RL J Biol Chem. 2002 Feb 22;277(8):5858-65.
RN [2]
RM PMID:15610020
RT Preparation and X-ray structures of metal-free, dicobalt and dimanganese forms of soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath).
RA Sazinsky MH, Merkx M, Cadieux E, Tang S, Lippard SJ
RL Biochemistry. 2004 Dec 28;43(51):16263-76.
RN [3]
RM PMID:23682956
RT Methanobactin and MmoD work in concert to act as the 'copper-switch' in methanotrophs.
RA Semrau JD, Jagadevan S, Dispirito AA, Khalifa A, Scanlan J, Bergman BH, Freemeier BC, Baral BS, Bandow NL, Vorobev A, Haft DH, Vuilleumier S, Murrell JC
RL Environ Microbiol. 2013 Apr 29. doi: 10.1111/1462-2920.12150. |