HMM Summary Page: TIGR04543
Accession | TIGR04543 |
Name | ketoArg_3Met |
Function | 2-ketoarginine methyltransferase |
Trusted Cutoff | 425.00 |
Domain Trusted Cutoff | 425.00 |
Noise Cutoff | 400.00 |
Domain Noise Cutoff | 400.00 |
Isology Type | equivalog |
EC Number | 2.1.1.243 |
HMM Length | 336 |
Author | Haft DH |
Entry Date | Jun 24 2014 2:41PM |
Last Modified | Jun 24 2014 2:41PM |
Comment | This SAM-dependent C-methyltransferase performs the middle step of a three step conversion from arginine to beta-methylarginine. It performs a C-methylation at position 3 of 5-guanidino-2-oxopentanoic acid (keto-arginine). An aminotransferase converts arginine to 5-guanidino-2-oxopentanoic acid, and later converts 5-guanidino-3-methyl-2-oxopentanoic acid to beta-methylarginine. |
References | RN [1] RM PMID:24907335 RT Biosynthesis of beta-Methylarginine residue of Peptidyl Nucleoside Arginomycin in Streptomyces arginensis NRRL 15941. RA Feng J, Wu J, Gao J, Xia Z, Deng Z, He X RL Appl Environ Microbiol. 2014 Jun 6. pii: AEM.01172-14. RN [2] RM PMID:20190091 RT Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93. RA Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D RL Appl Environ Microbiol. 2010 Apr;76(8):2500-8. doi: 10.1128/AEM.00666-09. |
Genome Property | GenProp1098: 3-methylarginine biosynthesis (HMM) |