HMM Summary Page: TIGR04543

AccessionTIGR04543
NameketoArg_3Met
Function2-ketoarginine methyltransferase
Trusted Cutoff425.00
Domain Trusted Cutoff425.00
Noise Cutoff400.00
Domain Noise Cutoff400.00
Isology Typeequivalog
EC Number2.1.1.243
HMM Length336
AuthorHaft DH
Entry DateJun 24 2014 2:41PM
Last ModifiedJun 24 2014 2:41PM
CommentThis SAM-dependent C-methyltransferase performs the middle step of a three step conversion from arginine to beta-methylarginine. It performs a C-methylation at position 3 of 5-guanidino-2-oxopentanoic acid (keto-arginine). An aminotransferase converts arginine to 5-guanidino-2-oxopentanoic acid, and later converts 5-guanidino-3-methyl-2-oxopentanoic acid to beta-methylarginine.
ReferencesRN [1] RM PMID:24907335 RT Biosynthesis of beta-Methylarginine residue of Peptidyl Nucleoside Arginomycin in Streptomyces arginensis NRRL 15941. RA Feng J, Wu J, Gao J, Xia Z, Deng Z, He X RL Appl Environ Microbiol. 2014 Jun 6. pii: AEM.01172-14. RN [2] RM PMID:20190091 RT Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93. RA Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D RL Appl Environ Microbiol. 2010 Apr;76(8):2500-8. doi: 10.1128/AEM.00666-09.
Genome PropertyGenProp1098: 3-methylarginine biosynthesis (HMM)