HMM Summary Page: TIGR04541

Functionthiamine pyridinylase
Gene SymbolbcmE
Trusted Cutoff175.00
Domain Trusted Cutoff175.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typeequivalog
EC Number2.5.1.2
HMM Length381
AuthorHaft DH
Entry DateJun 20 2014 4:25PM
Last ModifiedJun 20 2014 4:25PM
CommentMembers of this family are thiamine pyridinylase (EC, also called thiaminase I. Most examples of this secreted, thiamine-degrading enzyme are encoded with a cluster for biosynthesis of the thiamine antivitamin bacimethrin.
ReferencesRN [1] RM PMID:8631946 RT Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile. RA Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP RL J Biol Chem. 1996 Feb 16;271(7):3445-52. RN [2] RM PMID:24654570 RT Biosynthesis of a thiamin antivitamin in Clostridium botulinum. RA Cooper LE, O'Leary SE, Begley TP RL Biochemistry. 2014 Apr 15;53(14):2215-7. doi: 10.1021/bi500281a.
Genome PropertyGenProp1097: bacimethrin biosynthesis (HMM)