HMM Summary Page: TIGR04537

Functionencapsulation C-terminal sorting signal
Trusted Cutoff11.00
Domain Trusted Cutoff11.00
Noise Cutoff10.80
Domain Noise Cutoff10.80
Isology Typedomain
HMM Length11
AuthorHaft DH
Entry DateMay 15 2014 11:28AM
Last ModifiedSep 16 2014 4:02PM
CommentThis model describes a diverse region of extremely small size (11 residues), so unavoidably there are both false-positives and false-negatives. All true hits should occur in proteins encoded next to an encapsulating protein (see PF04454), and should occur near the extreme C-terminus. Families previously known to have this domain on some members to mediate encapsulation include dye-decolorizing peroxidases and a ferritin-like protein, but (as this model helps show) there are others, including some hemerythrin family proteins and novel family TIGR04536.
ReferencesRN [1] RM PMID:23560779 RT Assembly in vitro of Rhodococcus jostii RHA1 encapsulin and peroxidase DypB to form a nanocompartment. RA Rahmanpour R, Bugg TD RL FEBS J. 2013 May;280(9):2097-104. doi: 10.1111/febs.12234. RN [2] RM PMID:19172747 RT Structural basis of enzyme encapsulation into a bacterial nanocompartment. RA Sutter M, Boehringer D, Gutmann S, Gunther S, Prangishvili D, Loessner MJ, Stetter KO, Weber-Ban E, Ban N RL Nat Struct Mol Biol. 2008 Sep;15(9):939-47. doi: 10.1038/nsmb.1473.
Genome PropertyGenProp0810: encapsulin proteinaceous organelle (HMM)