HMM Summary Page: TIGR04532

Functionpolyketide product template domain
Trusted Cutoff168.00
Domain Trusted Cutoff168.00
Noise Cutoff165.00
Domain Noise Cutoff165.00
Isology Typesubfamily_domain
HMM Length329
AuthorHaft DH
Entry DateMay 6 2014 1:52PM
Last ModifiedSep 16 2014 4:02PM
CommentSequences found by this model are the so-called product template (PT) domain of various fungal iterative type I polyketide synthases. This domain resembles PF14765, designated polyketide synthase dehydratase by Pfam, but members of that family are primarily bacterial, where type I PKS are predominantly modular, not iterative. The dehydratase active site residues well-conserved in PF14765 (His in the first hot dog domain, Asp in the second hot dog domain) seem well conserved in this family also.
ReferencesRN [1] RM PMID:20479000 RT Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. RA Li Y, Image II, Xu W, Image I, Tang Y, Image I RL J Biol Chem. 2010 Jul 23;285(30):22764-73.