HMM Summary Page: TIGR04531

Functionputative nonproteinogenic amino acid hydroxylase
Trusted Cutoff300.00
Domain Trusted Cutoff300.00
Noise Cutoff180.00
Domain Noise Cutoff180.00
Isology Typesubfamily
EC Number1.14.-.-
HMM Length277
AuthorHaft DH
Entry DateMay 5 2014 9:21PM
Last ModifiedSep 16 2014 4:02PM
CommentThis extremely rare protein family, a branch of the 2-oxoglutarate dependent oxygenase family related to proline 3-hydroxylase, appears only in natural product biosynthetic clusters that include nonribosomal peptide synthases. One members is PlyP from the polyoxypeptin A cluster, suggested to hydroxylate 3-methylproline. Another, GetF from the GE81112 biosynthetic gene cluster, is a proposed to hydroxylate pipecolic acid.
ReferencesRN [1] RM PMID:24506891 RT Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer. RA Du Y, Wang Y, Huang T, Tao M, Deng Z, Lin S RL BMC Microbiol. 2014 Feb 8;14:30. doi: 10.1186/1471-2180-14-30. RN [2] RM PMID:20710026 RT Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster. RA Binz TM, Maffioli SI, Sosio M, Donadio S, Muller R RL J Biol Chem. 2010 Oct 22;285(43):32710-9. doi: 10.1074/jbc.M110.146803.