| Comment | This extremely rare protein family, a branch of the 2-oxoglutarate dependent oxygenase family related to proline 3-hydroxylase, appears only in natural product biosynthetic clusters that include nonribosomal peptide synthases. One members is PlyP from the polyoxypeptin A cluster, suggested to hydroxylate 3-methylproline. Another, GetF from the GE81112 biosynthetic gene cluster, is a proposed to hydroxylate pipecolic acid. |
| References | RN [1]
RM PMID:24506891
RT Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.
RA Du Y, Wang Y, Huang T, Tao M, Deng Z, Lin S
RL BMC Microbiol. 2014 Feb 8;14:30. doi: 10.1186/1471-2180-14-30.
RN [2]
RM PMID:20710026
RT Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.
RA Binz TM, Maffioli SI, Sosio M, Donadio S, Muller R
RL J Biol Chem. 2010 Oct 22;285(43):32710-9. doi: 10.1074/jbc.M110.146803. |
