HMM Summary Page: TIGR04530

Trusted Cutoff120.00
Domain Trusted Cutoff120.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typeequivalog
HMM Length118
AuthorHaft DH
Entry DateApr 28 2014 5:50PM
Last ModifiedSep 16 2014 4:02PM
CommentMembers of this family, including Rv0203 from Mycobacterium tuberculosis, are secreted heme-binding proteins used in heme acquisition. Such proteins are called hemophores. Members have a cleavable N-terminal signal peptide, and a mature region just over 100 amino acids long with a pair of invariant Cys residues. An unrelated hemophore, HasA, occurs in Gram-negative pathogens such as Yersinia pestis.
ReferencesRN [1] RM PMID:23760277 RT The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. RA Owens CP, Chim N, Graves AB, Harmston CA, Iniguez A, Contreras H, Liptak MD, Goulding CW RL J Biol Chem. 2013 Jul 26;288(30):21714-28. doi: 10.1074/jbc.M113.453076. DR PDB; 3MAY