HMM Summary Page: TIGR04529

Functionhemophore-related protein, Rv0203/Rv1174c family
Trusted Cutoff32.00
Domain Trusted Cutoff32.00
Noise Cutoff30.00
Domain Noise Cutoff29.00
Isology Typesubfamily
HMM Length77
AuthorHaft DH
Entry DateApr 24 2014 4:41PM
Last ModifiedApr 25 2014 10:34AM
CommentMembers of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa.
ReferencesRN [1] RM PMID:23760277 RT The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. RA Owens CP, Chim N, Graves AB, Harmston CA, Iniguez A, Contreras H, Liptak MD, Goulding CW RL J Biol Chem. 2013 Jul 26;288(30):21714-28. doi: 10.1074/jbc.M113.453076. RN [2] RM PMID:21383189 RT Discovery and characterization of a unique mycobacterial heme acquisition system. RA Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW RL Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5051-6. RN [3] RM PMID:11101579 RT Distinct differences in repertoires of low-molecular-mass secreted antigens of Mycobacterium avium complex and Mycobacterium tuberculosis. RA Olsen I, Reitan LJ, Wiker HG RL J Clin Microbiol. 2000 Dec;38(12):4453-8. RN [4] RM PMID:16828326 RT The secretion antigen SA5K has a role in the adaptation of Mycobacterium bovis bacillus Calmette-Guerin to intracellular stress and hypoxia. RA Bottai D, Batoni G, Esin S, Florio W, Brancatisano FL, Favilli F, Maisetta G, Campa M RL Microbes Infect. 2006 Jul;8(8):2254-61.