HMM Summary Page: TIGR04525

FunctionIgG-blocking protein M
Trusted Cutoff140.00
Domain Trusted Cutoff140.00
Noise Cutoff40.00
Domain Noise Cutoff40.00
Isology Typeequivalog
HMM Length526
AuthorHaft DH
Entry DateApr 7 2014 11:06AM
Last ModifiedSep 16 2014 4:02PM
CommentMembers of this family, including MG_281 of Mycoplasma genitalium, bind conserved regions of the IgG light chain sequences, blocking IgG's normal function of antigen-specific binding. It is therefore an important virulence protein. Members of this family are found also in Mycoplasma pneumoniae, M. penetrans, M. gallisepticum, and M. iowae. Model TIGR04524 describes a region within this protein that is shared by many additional Mycoplasma and Ureaplasma proteins.
ReferencesRN [1] RM PMID:24503852 RT A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. RA Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA RL Science. 2014 Feb 7;343(6171):656-61. doi: 10.1126/science.1246135.