HMM Summary Page: TIGR04524

FunctionIgG-blocking virulence domain
Trusted Cutoff40.00
Domain Trusted Cutoff40.00
Noise Cutoff28.00
Domain Noise Cutoff24.00
Isology Typedomain
HMM Length253
AuthorHaft DH
Entry DateApr 7 2014 10:44AM
Last ModifiedSep 16 2014 4:02PM
CommentThis model defines a domain restricted to Mycoplasma and Ureaplasma proteins. Members include protein M of Mycoplasma genitalium, MG_281, a virulence protein that binds the IgG light chain to block the binding of antibody to antigen. The crystal structure of the protein M antibody-binding region is solved (PDB|4NZR), and includes this homology domain. Full-length homologs to MG_281 are known in a few other Mycoplasma species, but this model's seed alignment demonstrates distant homology to many additional proteins with a much wider distribution across the Mollicutes. Member proteins include paralogous families in some species, such as MCAP_0345, MCAP_0347, MCAP_0349, and MCAP_0351 in Mycoplasma capricolum.
ReferencesRN [1] RM PMID:24503852 RT A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union. RA Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA RL Science. 2014 Feb 7;343(6171):656-61. doi: 10.1126/science.1246135.