HMM Summary Page: TIGR04517
Accession | TIGR04517 |
Name | rSAM_PoyD |
Function | radical SAM family RiPP maturation amino acid epimerase |
Trusted Cutoff | 325.00 |
Domain Trusted Cutoff | 325.00 |
Noise Cutoff | 300.00 |
Domain Noise Cutoff | 300.00 |
Isology Type | subfamily |
HMM Length | 446 |
Author | Haft DH |
Entry Date | Mar 10 2014 8:46PM |
Last Modified | Mar 10 2014 8:47PM |
Comment | This HMM describes PoyD and its homologs. These are divergent putative radical SAM enzymes, with the classical CxxxCxxC motif but with few members approaching the cutoff score of Pfam model PF04055. PoyD appears responsible for catalyzing a unidirectional L-to-D epimerization of 18 the 48 residues in the core peptide of the first characterized polytheonamide. The RiPP (ribosomally translated natural product) precursor, and peptides encoded near many other members of this family, belong to the nitrile hydratase leader peptide (NHLP) family. |
References | RN [1] RM PMID:22983711 RT Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. RA Freeman MF, Gurgui C, Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl HG, Matsunaga S, Piel J RL Science. 2012 Oct 19;338(6105):387-90. doi: 10.1126/science.1226121. |