HMM Summary Page: TIGR04517

Functionradical SAM family RiPP maturation amino acid epimerase
Trusted Cutoff325.00
Domain Trusted Cutoff325.00
Noise Cutoff300.00
Domain Noise Cutoff300.00
Isology Typesubfamily
HMM Length446
AuthorHaft DH
Entry DateMar 10 2014 8:46PM
Last ModifiedMar 10 2014 8:47PM
CommentThis HMM describes PoyD and its homologs. These are divergent putative radical SAM enzymes, with the classical CxxxCxxC motif but with few members approaching the cutoff score of Pfam model PF04055. PoyD appears responsible for catalyzing a unidirectional L-to-D epimerization of 18 the 48 residues in the core peptide of the first characterized polytheonamide. The RiPP (ribosomally translated natural product) precursor, and peptides encoded near many other members of this family, belong to the nitrile hydratase leader peptide (NHLP) family.
ReferencesRN [1] RM PMID:22983711 RT Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides. RA Freeman MF, Gurgui C, Helf MJ, Morinaka BI, Uria AR, Oldham NJ, Sahl HG, Matsunaga S, Piel J RL Science. 2012 Oct 19;338(6105):387-90. doi: 10.1126/science.1226121.