HMM Summary Page: TIGR04515

FunctionP450-derived glycosyltranferase activator
Trusted Cutoff343.00
Domain Trusted Cutoff343.00
Noise Cutoff280.00
Domain Noise Cutoff280.00
Isology Typesubfamily
HMM Length386
AuthorHaft DH
Entry DateMar 4 2014 2:18PM
Last ModifiedSep 16 2014 4:02PM
CommentMembers of this family resemble cytochrome P450 by homolog, but lack a critical heme-binding Cys residue. Members in general are encoded next to a glycosyltransferase gene in a natural products biosynthesis cluster, physically interact with it, and help the glycosyltransferase achieve high specificity while retaining high activity. Many members of this family assist in the attachment of a sugar moiety to a natural product such as a polyketide.
ReferencesRN [1] RM PMID:22056329 RT Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII. RA Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF RL J Mol Biol. 2012 Jan 6;415(1):92-101. doi: 10.1016/j.jmb.2011.10.036.