HMM Summary Page: TIGR04507

Functionadenosyl-fluoride synthase
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff225.00
Domain Noise Cutoff225.00
Isology Typeequivalog
EC Number2.5.1.63
HMM Length286
AuthorHaft DH
Entry DateJan 20 2014 12:05AM
Last ModifiedJan 20 2014 12:05AM
CommentMembers of this family are fluorinase (adenosyl-fluoride synthase, EC, an enzyme involved in the first committed step in the biosynthesis of at least two different organofluorine compounds. Few organofluorine natural products are known. Related enzymes include chlorinases (EC that lack fluorinase activity, although a fluorinase may show chlorinase activity.
ReferencesRN [1] RM PMID:16604208 RT Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates. RA Cobb SL, Deng H, McEwan AR, Naismith JH, O'Hagan D, Robinson DA RL Org Biomol Chem. 2006 Apr 21;4(8):1458-60.