HMM Summary Page: TIGR04499

Functionabortive infection protein, AbiA family
Trusted Cutoff250.00
Domain Trusted Cutoff250.00
Noise Cutoff150.00
Domain Noise Cutoff150.00
Isology Typesubfamily
HMM Length615
AuthorHaft DH
Entry DateDec 6 2013 10:53AM
Last ModifiedDec 6 2013 10:53AM
CommentMembers of this protein family average about 650 amino acids in length, with an N-terminal region related to reverse transcriptases. The only characterized member is AbiA, with reported activity as an abortive infection protein for phage defense in Lactococcus lactis and (heterologously) in Streptococcus thermophilus.
ReferencesRN [1] RM PMID:12450864 RT AbiA, a lactococcal abortive infection mechanism functioning in Streptococcus thermophilus. RA Tangney M, Fitzgerald GF RL Appl Environ Microbiol. 2002 Dec;68(12):6388-91.