HMM Summary Page: TIGR04492

Functioniminophenyl-pyruvate dimer synthase VioB
Gene SymbolvioB
Trusted Cutoff1250.00
Domain Trusted Cutoff1250.00
Noise Cutoff1100.00
Domain Noise Cutoff1100.00
Isology Typeequivalog
HMM Length1003
AuthorHaft DH
Entry DateOct 30 2013 4:07PM
Last ModifiedOct 30 2013 4:07PM
CommentFollowing the action of a flavin-dependent L-amino acid oxidase that converts L-tryptophan to indole-3-pyruvate imine, the enzymes VioB (this family), RebD, and StaD can ligate two molecules, forming a coupled iminophenyl-pyruvate dimer. In the violacein biosynthesis pathway, this compound is acted on by VioE before it cyclizes spontaneously to chromopyrrolic acid. In the pathways of homolog StaD (staurosporine), chromopyrrolate is formed, and the enzyme is referred to as chromopyrrolate synthase. RebD is very similar to StaD, but acts on chlorinated Trp-derived molecules.
ReferencesRN [1] RM PMID:19389622 RT Divergent pathways in the biosynthesis of bisindole natural products. RA Ryan KS, Drennan CL RL Chem Biol. 2009 Apr 24;16(4):351-64. doi: 10.1016/j.chembiol.2009.01.017.