| Accession | TIGR04491 |
| Name | reactive_PduG |
| Function | diol dehydratase reactivase alpha subunit |
| Trusted Cutoff | 400.00 |
| Domain Trusted Cutoff | 400.00 |
| Noise Cutoff | 100.00 |
| Domain Noise Cutoff | 100.00 |
| Isology Type | equivalog |
| HMM Length | 599 |
| Author | Haft DH |
| Entry Date | Oct 30 2013 2:23PM |
| Last Modified | Oct 30 2013 2:23PM |
| Comment | Members of this family are the alpha (large) subunit of the alpha-2/beta-2 tetrameric enzyme that reactivates B12-dependent trimeric diol dehydratases (1,2-propanediol dehydratase, glycerol dehydratase). Note that the beta subunit of the reactivase is homologous to the beta (medium) subunit of the diol dehydratase. The reactivase catalyzes the exchange of chemically inactivated B-12 for active B12. This model excludes homologs from Mycobacterium (e.g. M. smegmatis), where the several paralogous forms of the dehydratase occur and are exceptional also by not being found in a carboxysome-like microcompartment. |
| References | RN [1]
RM PMID:21040475
RT Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase.
RA Mori K, Hosokawa Y, Yoshinaga T, Toraya T
RL FEBS J. 2010 Dec;277(23):4931-43. doi: 10.1111/j.1742-4658.2010.07898.x. |
| Genome Property | GenProp1089: B12-dependent trimeric diol/glycerol dehydratase (HMM) |
