HMM Summary Page: TIGR04491

Functiondiol dehydratase reactivase alpha subunit
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typeequivalog
HMM Length599
AuthorHaft DH
Entry DateOct 30 2013 2:23PM
Last ModifiedOct 30 2013 2:23PM
CommentMembers of this family are the alpha (large) subunit of the alpha-2/beta-2 tetrameric enzyme that reactivates B12-dependent trimeric diol dehydratases (1,2-propanediol dehydratase, glycerol dehydratase). Note that the beta subunit of the reactivase is homologous to the beta (medium) subunit of the diol dehydratase. The reactivase catalyzes the exchange of chemically inactivated B-12 for active B12. This model excludes homologs from Mycobacterium (e.g. M. smegmatis), where the several paralogous forms of the dehydratase occur and are exceptional also by not being found in a carboxysome-like microcompartment.
ReferencesRN [1] RM PMID:21040475 RT Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase. RA Mori K, Hosokawa Y, Yoshinaga T, Toraya T RL FEBS J. 2010 Dec;277(23):4931-43. doi: 10.1111/j.1742-4658.2010.07898.x.
Genome PropertyGenProp1089: B12-dependent trimeric diol/glycerol dehydratase (HMM)