| Accession | TIGR04480 |
| Name | D_pro_red_PrdA |
| Function | D-proline reductase (dithiol), PrdA proprotein |
| Gene Symbol | prdA |
| Trusted Cutoff | 700.00 |
| Domain Trusted Cutoff | 700.00 |
| Noise Cutoff | 350.00 |
| Domain Noise Cutoff | 350.00 |
| Isology Type | equivalog |
| EC Number | 1.21.4.1 |
| HMM Length | 587 |
| Author | Haft DH |
| Entry Date | Sep 13 2013 1:37PM |
| Last Modified | Sep 13 2013 1:37PM |
| Comment | Members of this family are the PrdA proprotein. The polypeptide undergoes an autocatalytic cleavage that creates two subunits, one with a Cys-derived pyruvoyl motiety critical for activity. The D-proline reductase complex also contains a subunit derived from the prdB gene. The complex acts on D-proline, which may be supplied from L-proline by an active proline racemase encoded nearby. |
| References | RN [1]
RM PMID:23222730
RT Proline-dependent regulation of Clostridium difficile Stickland metabolism.
RA Bouillaut L, Self WT, Sonenshein AL
RL J Bacteriol. 2013 Feb;195(4):844-54. doi: 10.1128/JB.01492-12. |
