HMM Summary Page: TIGR04480

FunctionD-proline reductase (dithiol), PrdA proprotein
Gene SymbolprdA
Trusted Cutoff700.00
Domain Trusted Cutoff700.00
Noise Cutoff350.00
Domain Noise Cutoff350.00
Isology Typeequivalog
EC Number1.21.4.1
HMM Length587
AuthorHaft DH
Entry DateSep 13 2013 1:37PM
Last ModifiedSep 13 2013 1:37PM
CommentMembers of this family are the PrdA proprotein. The polypeptide undergoes an autocatalytic cleavage that creates two subunits, one with a Cys-derived pyruvoyl motiety critical for activity. The D-proline reductase complex also contains a subunit derived from the prdB gene. The complex acts on D-proline, which may be supplied from L-proline by an active proline racemase encoded nearby.
ReferencesRN [1] RM PMID:23222730 RT Proline-dependent regulation of Clostridium difficile Stickland metabolism. RA Bouillaut L, Self WT, Sonenshein AL RL J Bacteriol. 2013 Feb;195(4):844-54. doi: 10.1128/JB.01492-12.