HMM Summary Page: TIGR04477

FunctionXrtN system VIT domain protein
Trusted Cutoff250.00
Domain Trusted Cutoff250.00
Noise Cutoff125.00
Domain Noise Cutoff125.00
Isology Typehypoth_equivalog
HMM Length822
AuthorHaft DH
Entry DateAug 30 2013 2:51PM
Last ModifiedAug 30 2013 2:51PM
CommentMembers of this subfamily average about 850 amino acids in length, ending with a variant form of PEP-CTERM sorting signal. Members have a VIT (vault protein inter-alpha-trypsin inhibitor heavy chain) domain (PF08487). Other bacterial subfamilies of VIT domain proteins have members with either GlyGly-CTERM or LPXTG C-terminal sorting signals. Members of this subfamily occur only in context next to a protein sorting/processing enzyme, exosortase N (XrtN). These subsystems occur both among the Bacteriodetes and in the spirochete genus Leptospira.
ReferencesRN [1] RM PMID:22037399 RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. RA Haft DH, Payne SH, Selengut JD RL J Bacteriol. 2012 Jan;194(1):36-48. doi: 10.1128/JB.06026-11.
Genome PropertyGenProp1087: protein sorting system, vault protein/exosortase N (HMM)