HMM Summary Page: TIGR04475

Functionphenylalanine aminomutase (D-beta-phenylalanine forming)
Trusted Cutoff800.00
Domain Trusted Cutoff800.00
Noise Cutoff525.00
Domain Noise Cutoff525.00
Isology Typeequivalog
EC Number5.4.3.11
HMM Length510
AuthorHaft DH
Entry DateAug 28 2013 6:43PM
Last ModifiedAug 28 2013 6:43PM
CommentMembers of this family have the MIO prosthetic group (4-methylideneimidazole-5-one), derived from an Ala-Ser-Gly motif. Other MIO enzymes include Phe, Tyr, and His ammonia-lyases. The member from Pantoea agglomerans, and probably all members, convert Phe to D-beta-phenylalanine (EC By contrast, members of family TIGR04473 convert Phe to L-beta-phenylalanine (, as in taxol biosynthesis.
ReferencesRN [1] RM PMID:21561099 RT Stereochemistry and mechanism of a microbial phenylalanine aminomutase. RA Ratnayake ND, Wanninayake U, Geiger JH, Walker KD RL J Am Chem Soc. 2011 Jun 8;133(22):8531-3. doi: 10.1021/ja2030728.