HMM Summary Page: TIGR04475
| Accession | TIGR04475 |
| Name | Phe_D_beta_mut |
| Function | phenylalanine aminomutase (D-beta-phenylalanine forming) |
| Trusted Cutoff | 800.00 |
| Domain Trusted Cutoff | 800.00 |
| Noise Cutoff | 525.00 |
| Domain Noise Cutoff | 525.00 |
| Isology Type | equivalog |
| EC Number | 5.4.3.11 |
| HMM Length | 510 |
| Author | Haft DH |
| Entry Date | Aug 28 2013 6:43PM |
| Last Modified | Aug 28 2013 6:43PM |
| Comment | Members of this family have the MIO prosthetic group (4-methylideneimidazole-5-one), derived from an Ala-Ser-Gly motif. Other MIO enzymes include Phe, Tyr, and His ammonia-lyases. The member from Pantoea agglomerans, and probably all members, convert Phe to D-beta-phenylalanine (EC 5.4.3.11). By contrast, members of family TIGR04473 convert Phe to L-beta-phenylalanine (5.4.3.10), as in taxol biosynthesis. |
| References | RN [1] RM PMID:21561099 RT Stereochemistry and mechanism of a microbial phenylalanine aminomutase. RA Ratnayake ND, Wanninayake U, Geiger JH, Walker KD RL J Am Chem Soc. 2011 Jun 8;133(22):8531-3. doi: 10.1021/ja2030728. |