HMM Summary Page: TIGR04473

Functionphenylalanine aminomutase (L-beta-phenylalanine forming)
Gene Symbolpam
Trusted Cutoff1250.00
Domain Trusted Cutoff1250.00
Noise Cutoff850.00
Domain Noise Cutoff850.00
Isology Typeexception
EC Number5.4.3.10
HMM Length687
AuthorHaft DH
Entry DateAug 27 2013 2:04PM
Last ModifiedAug 27 2013 2:04PM
CommentMembers of this family are the phenylalanine aminomutase known from taxol biosynthesis. This enzyme has the MIO prosthetic group (4-methylideneimidazole-5-one), derived from an Ala-Ser-Gly motif. Other MIO enzymes include Phe, Tyr, and His ammonia-lyases. This model serves as an exception to overrule assignments by equivalog model TIGR01226 for phenylalanine ammonia-lyase.
ReferencesRN [1] RM PMID:15494399 RT Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in Taxol biosynthesis. RA Walker KD, Klettke K, Akiyama T, Croteau R RL J Biol Chem. 2004 Dec 24;279(52):53947-54.