HMM Summary Page: TIGR04469

FunctionCGA synthase-related protein
Gene SymbolblsF
Trusted Cutoff150.00
Domain Trusted Cutoff150.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typeequivalog
HMM Length297
AuthorHaft DH
Entry DateAug 18 2013 9:15PM
Last ModifiedAug 18 2013 9:15PM
CommentMembers of this family are related to cytosylglucuronate (CGA) synthase (TIGR04466), and found in the same clusters as CGA synthase and CGA decarboxylase. These clusters produce peptidyl nucleoside antibiotics with a pyranoside core moiety, found in a number of Streptomyces species. Removal of the S. griseochromogenes member of this family, BlsF, from a heterologous expression system caused an increase, not blockage, of blasticidin S.
ReferencesRN [1] RM PMID:23377931 RT Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation. RA Li L, Wu J, Deng Z, Zabriskie TM, He X RL Appl Environ Microbiol. 2013 Apr;79(7):2349-57. doi: 10.1128/AEM.03254-12.