HMM Summary Page: TIGR04468

Functionarginine 2,3-aminomutase
Gene SymbolblsG
Trusted Cutoff600.00
Domain Trusted Cutoff600.00
Noise Cutoff500.00
Domain Noise Cutoff500.00
Isology Typeequivalog
EC Number5.4.3.-
HMM Length351
AuthorHaft DH
Entry DateAug 17 2013 3:27PM
Last ModifiedAug 17 2013 3:27PM
CommentMembers of this family are arginine 2,3-aminomutase, a radical SAM enzyme more closely related to lysine 2,3-aminomutase than to glutamate 2,3-aminomutase. The enzyme makes L-beta-arginine, sometimes in the context of antibiotic biosynthesis (blasticidin S, mildiomycin, etc). Activity is proven in Streptomyces griseochromogenes, which makes blasticidin S.
ReferencesRN [1] RT Biosynthesis of blasticidin S from L-alpha-arginine. Stereochemistry in the arginine-2,3-aminomutase reaction. RA Prabhakaran PC, Woo NT, Yorgey PS, Gould SJ RL J. Am. Chem. Soc., 1988, 110 (17), 57855791