| Accession | TIGR04467 |
| Name | CGA_synthase |
| Function | hydroxymethylcytosylglucuronate/cytosylglucuronate synthase |
| Trusted Cutoff | 300.00 |
| Domain Trusted Cutoff | 300.00 |
| Noise Cutoff | 100.00 |
| Domain Noise Cutoff | 100.00 |
| Isology Type | equivalog |
| EC Number | 2.4.1.- |
| HMM Length | 382 |
| Author | Haft DH |
| Entry Date | Aug 17 2013 3:14PM |
| Last Modified | Aug 17 2013 3:14PM |
| Comment | Members of this family synthesize cytosylglucuronate (or hydroxymethylcytosylglucuronate) from UDP-glucuronate and free cytosine (or hydroxymethylcytosine). This reaction is followed by a decarboxylation at C5 of the glucoside residue. The net reaction makes the pyranoside core moiety of a class of peptidyl nucleoside antibiotics. |
| References | RN [1]
RM PMID:22753012
RT Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase.
RA Wu J, Li L, Deng Z, Zabriskie TM, He X
RL Chembiochem. 2012 Jul 23;13(11):1613-21. doi: 10.1002/cbic.201200173. |
| Genome Property | GenProp1085: pyranoside core peptidyl nucleoside antibiotic biosynthesis (HMM) |
