HMM Summary Page: TIGR04466

Functioncytosylglucuronate decarboxylase
Gene SymbolblsE
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff125.00
Domain Noise Cutoff125.00
Isology Typeequivalog
EC Number4.1.-.-
HMM Length327
AuthorHaft DH
Entry DateAug 17 2013 1:27PM
Last ModifiedAug 17 2013 1:27PM
CommentBlsE, part of the blasticidin S biosynthetic pathway, is a radical SAM enzyme that performs a decarboxylation at C5 of the glucoside residue. MilG in mildiomycin biosynthesis is equivalent. This enzyme follows CGA synthase and makes the pyranoside core moiety of a class of peptidyl nucleoside antibiotics.
ReferencesRN [1] RM PMID:23874663 RT Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway. RA Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z, He X RL PLoS One. 2013 Jul 18;8(7):e68545. doi: 10.1371/journal.pone.0068545.
Genome PropertyGenProp1085: pyranoside core peptidyl nucleoside antibiotic biosynthesis (HMM)