HMM Summary Page: TIGR04466
Accession | TIGR04466 |
Name | rSAM_BlsE |
Function | cytosylglucuronate decarboxylase |
Gene Symbol | blsE |
Trusted Cutoff | 400.00 |
Domain Trusted Cutoff | 400.00 |
Noise Cutoff | 125.00 |
Domain Noise Cutoff | 125.00 |
Isology Type | equivalog |
EC Number | 4.1.-.- |
HMM Length | 327 |
Author | Haft DH |
Entry Date | Aug 17 2013 1:27PM |
Last Modified | Aug 17 2013 1:27PM |
Comment | BlsE, part of the blasticidin S biosynthetic pathway, is a radical SAM enzyme that performs a decarboxylation at C5 of the glucoside residue. MilG in mildiomycin biosynthesis is equivalent. This enzyme follows CGA synthase and makes the pyranoside core moiety of a class of peptidyl nucleoside antibiotics. |
References | RN [1] RM PMID:23874663 RT Discovery and Characterization of BlsE, a Radical S-Adenosyl-L-methionine Decarboxylase Involved in the Blasticidin S Biosynthetic Pathway. RA Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z, He X RL PLoS One. 2013 Jul 18;8(7):e68545. doi: 10.1371/journal.pone.0068545. |
Genome Property | GenProp1085: pyranoside core peptidyl nucleoside antibiotic biosynthesis (HMM) |