HMM Summary Page: TIGR04464

FunctionLipL41-expression chaperone Lep
Gene Symbollep
Trusted Cutoff60.00
Domain Trusted Cutoff60.00
Noise Cutoff33.00
Domain Noise Cutoff25.00
Isology Typeequivalog
HMM Length114
AuthorHaft DH
Entry DateJul 24 2013 11:47AM
Last ModifiedJul 24 2013 11:47AM
CommentMembers of this protein family are Lep, an outer membrane lipoprotein LipL41-binding protein that appears to function as a chaperone important to its expression. LipL41 is the third most abundant lipoprotein in the pathogen Leptospira interrogans, but is found in saprophytic Leptospira species as well and is not essential for virulence.
ReferencesRN [1] RM PMID:23690405 RT Leptospiral Outer Membrane Protein LipL41 Is Not Essential for Acute Leptospirosis but Requires a Small Chaperone Protein, Lep, for Stable Expression. RA King AM, Bartpho T, Sermswan RW, Bulach DM, Eshghi A, Picardeau M, Adler B, Murray GL RL Infect Immun. 2013 Aug;81(8):2768-76.