HMM Summary Page: TIGR04461

Functionenduracididine biosynthesis enzyme MppQ
Gene SymbolmppQ
Trusted Cutoff540.00
Domain Trusted Cutoff540.00
Noise Cutoff400.00
Domain Noise Cutoff400.00
Isology Typeequivalog
EC Number2.-.-.-
HMM Length392
AuthorHaft DH
Entry DateJul 16 2013 4:37PM
Last ModifiedJul 16 2013 4:37PM
CommentMembers of this family are MppQ, one of three enzymes involved in synthesizing enduracididine, a non-proteinogenic amino acid used in non-ribosomal peptide synthases to make natural products such as enduracidin from Streptomyces fungicidicus ATCC 21013. MppQ is a PLP-dependent enzyme, predicted by homology to be an aminotransferase.
ReferencesRN [1] RM PMID:23758195 RT Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily. RA Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR RL Biochemistry. 2013 Jul 2;52(26):4492-506. doi: 10.1021/bi400397k.
Genome PropertyGenProp1084: enduracididine biosynthesis (HMM)