Comment | Members of this family are the TisB toxin protein of a type I toxin-antitoxin system, meaning that the antitoxin is a non-coding RNA. TisB is induced by some types of stress (SOS, ciprofloxacin) and appears to induce a persister state by dissipating transmembrane potential, thus depleting ATP. Persister cells, unable to grow until the persister state changes, survive a number of challenges, including exposure to most antibiotics. |
References | RN [1]
RM PMID:18761622
RT A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli.
RA Unoson C, Wagner EG
RL Mol Microbiol. 2008 Oct;70(1):258-70. doi: 10.1111/j.1365-2958.2008.06416.x.
RN [2]
RM PMID:23062338
RT Peptide-lipid interactions of the stress-response peptide TisB that induces bacterial persistence.
RA Steinbrecher T, Prock S, Reichert J, Wadhwani P, Zimpfer B, Burck J, Berditsch M, Elstner M, Ulrich AS
RL Biophys J. 2012 Oct 3;103(7):1460-9. doi: 10.1016/j.bpj.2012.07.060.
RN [3]
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RT Persister-promoting bacterial toxin TisB produces anion-selective pores in planar lipid bilayers.
RA Gurnev PA, Ortenberg R, Dorr T, Lewis K, Bezrukov SM
RL FEBS Lett. 2012 Jul 30;586(16):2529-34. doi: 10.1016/j.febslet.2012.06.021. |