HMM Summary Page: TIGR04458

Function4-nitrotryptophan synthase
Gene SymboltxtE
Trusted Cutoff500.00
Domain Trusted Cutoff500.00
Noise Cutoff250.00
Domain Noise Cutoff250.00
Isology Typeequivalog
EC Number1.-.-.-
HMM Length403
AuthorHaft DH
Entry DateJun 29 2013 5:57PM
Last ModifiedJun 29 2013 5:57PM
CommentMembers of this family are cytochrome P450 enzymes that convert L-tryptophan into L-4-nitrotryptophan. In thaxtomin gene clusters, this enzyme (TxtE) uses nitric acid (NO) derived from arginine by the nitric oxide synthase TxtD, and O2, to perform the tryptophan nitration. L-4-nitrotryptophan is then used as a non-proteinogenic amino acid by non-ribosomal peptide synthases (NRPS).
ReferencesRN [1] RM PMID:22941045 RT Cytochrome P450-catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. RA Barry SM, Kers JA, Johnson EG, Song L, Aston PR, Patel B, Krasnoff SB, Crane BR, Gibson DM, Loria R, Challis GL RL Nat Chem Biol. 2012 Oct;8(10):814-6.