HMM Summary Page: TIGR04457

Functionlipoprotein LenA
Gene SymbollenA
Trusted Cutoff50.00
Domain Trusted Cutoff50.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typeequivalog
HMM Length224
AuthorHaft DH
Entry DateJun 24 2013 12:07PM
Last ModifiedJun 24 2013 12:07PM
CommentMembers of this family are LenA (Leptospira Endostatin-like protein A), found in pathogenic and intermediate species of Leptospira but not in saprophytes. LenA binds plasminogen, laminin, and complement regulator factor H. Behavior during outer membrane solubilization by low concentrations of Triton X-114 and conservation in all family members of an apparent lipoprotein signal sequence, with invariant Cys residue, strongly suggest that LenA is a lipoprotein. Just outside this family is a full-length homolog found in another spirochete, Turneriella parva DSM 21527.
ReferencesRN [1] RM PMID:20160016 RT Leptospiral endostatin-like protein A is a bacterial cell surface receptor for human plasminogen. RA Verma A, Brissette CA, Bowman AA, Shah ST, Zipfel PF, Stevenson B RL Infect Immun. 2010 May;78(5):2053-9. doi: 10.1128/IAI.01282-09.