HMM Summary Page: TIGR04449

Functionhalocin C8-like bacteriocin domain
Trusted Cutoff24.00
Domain Trusted Cutoff24.00
Noise Cutoff22.50
Domain Noise Cutoff20.00
Isology Typesubfamily_domain
HMM Length69
AuthorHaft DH
Entry DateJun 13 2013 9:48AM
Last ModifiedJun 13 2013 9:48AM
CommentThis HMM describes the 76-amino C-terminal domain of the halocin C8 precursor that actually becomes the mature bacteriocin halocin C8 after export and cleavage, as well as homologous C-terminal regions from many other archaea. Surprisingly, this Cys-rich region occurs also in many strains of Staphylococcus epidermidis. Gene regions do not provide evidence for post-translational modification other than cleavage. Halocin C8 is active against a broad range of archaea; the region N-terminal to the bacteriocin domain modeled here serves as the immunity protein for the cell secreting the bacteriocin.
ReferencesRN [1] RM PMID:18658263 RT The helix-loop-helix motif at the N terminus of HalI is essential for its immunity function against halocin C8. RA Mei S, Sun C, Liu X, Lu Q, Cai L, Li Y, Xiang H RL J Bacteriol. 2008 Oct;190(19):6501-8.