HMM Summary Page: TIGR04447

Functioncyanobactin cluster PatC/TenC/TruC protein
Trusted Cutoff30.00
Domain Trusted Cutoff30.00
Noise Cutoff25.00
Domain Noise Cutoff20.00
Isology Typedomain
HMM Length34
AuthorHaft DH
Entry DateJun 7 2013 4:51PM
Last ModifiedJun 7 2013 4:51PM
CommentMembers of this family usually are small proteins (PatC, TenC, TruC) of unknown function in cyanobactin (prenylated cyclic peptide) biosynthesis clusters, where a different small protein is a known cyanobactin precursor (patellamide, anacyclamide, piricyclamide, etc). They may instead be the C-terminal domain of a longer protein that otherwise consists mostly of lectin-like or VWF type A domains, in similar context. Similar to the cyanobactin precursors, members of this family have two very strongly conserved regions separated by a hypervariable region, suggesting these proteins may undergo a similar maturation.
ReferencesRN [1] RM PMID:15883371 RT Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. RA Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J RL Proc Natl Acad Sci U S A. 2005 May 17;102(20):7315-20.
Genome PropertyGenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM)