HMM Summary Page: TIGR04445

Functionpeptide O-prenyltransferase, LynF/TruF/PatF family
Trusted Cutoff140.00
Domain Trusted Cutoff140.00
Noise Cutoff30.00
Domain Noise Cutoff30.00
Isology Typesubfamily
EC Number2.5.1.-
HMM Length282
AuthorHaft DH
Entry DateJun 5 2013 8:25PM
Last ModifiedJun 5 2013 8:25PM
CommentMembers of this family are prenytransferases that modify mostly, perhaps exclusively, ribosomally derived cyclic peptides. Note that in some cases, the natural product becomes C-prenylated through a non-enzymatic rearrangement after initial O-prenylation. Prenylated products carry names such as prenylagaramide, anacyclamide, and piricyclamide.
ReferencesRN [1] RM PMID:21766822 RT Enzymatic basis of ribosomal peptide prenylation in cyanobacteria. RA McIntosh JA, Donia MS, Nair SK, Schmidt EW RL J Am Chem Soc. 2011 Aug 31;133(34):13698-705.
Genome PropertyGenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM)