HMM Summary Page: TIGR04444

Functionchorismatase, FkbO/Hyg5 family
Trusted Cutoff325.00
Domain Trusted Cutoff325.00
Noise Cutoff275.00
Domain Noise Cutoff275.00
Isology Typesubfamily
EC Number4.1.3.-
HMM Length311
AuthorHaft DH
Entry DateJun 3 2013 5:50PM
Last ModifiedJun 3 2013 5:50PM
CommentMembers of this include two chemically distinct enzymes that cleave pyruvate from chorismate. FkbO and RapK convert chorismate to pyruvate plus (4R,5R)-4,5-dihydroxycyclohexa-1,5-dienecarboxylic acid (DCDC). HygB and Bra8 convert chorismate to pyruvate, water, and 3-hydroxybenzoate. These two enzymes are closely related, and lack homology to chorismate lyase, EC, which converts chorismate to pyruvate plus 4-hydroxybenzoate.
ReferencesRN [1] RM PMID:21383123 RT Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. RA Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B RL Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4776-81.