HMM Summary Page: TIGR04443

Functioncoenzyme gamma-F420-2:alpha-L-glutamate ligase
Gene SymbolcofF
Trusted Cutoff300.00
Domain Trusted Cutoff300.00
Noise Cutoff150.00
Domain Noise Cutoff150.00
Isology Typeequivalog
EC Number6.3.2.32
HMM Length283
AuthorHaft DH
Entry DateMay 24 2013 3:22PM
Last ModifiedMay 24 2013 3:22PM
CommentMembers of this family are the CofF, a RimK-related glutamate ligase that caps the gamma-glutamyl tail of the archaeal form of coenzyme F420, a hydride carrier. This enzyme does not appear in bacterial species, such as Mycobacterium tuberculosis, that make F420 with a different type of tail.
ReferencesRN [1] RM PMID:12909715 RT Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses. RA Li H, Xu H, Graham DE, White RH RL Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9785-90.
Genome PropertyGenProp0791: coenzyme F420 biosynthesis (HMM)