HMM Summary Page: TIGR04433

FunctionUrcA family protein
Trusted Cutoff25.00
Domain Trusted Cutoff24.00
Noise Cutoff23.00
Domain Noise Cutoff23.00
Isology Typesubfamily
HMM Length92
AuthorHaft DH
Entry DateApr 22 2013 10:18PM
Last ModifiedApr 22 2013 10:18PM
CommentMembers of this family feature an N-terminal signal sequence, small size, and two invariant Cys residues, 10-20 residues apart. One member of this family, UrcA from the aerobic bacterium Caulobacter crescentus, is expressed so highly in response to uranium, but not other heavy metals, that a genetically engineered strain expressing green fluorescent protein in place of UrcA serves as a biodetector for micromolar uranyl ion. Caulobacter crescentus tolerates high levels of U(VI) exposure by mineralizing the uranium. UrcA and its homologs may participate in such a process.
ReferencesRN [1] RM PMID:17905881 RT Caulobacter crescentus as a whole-cell uranium biosensor. RA Hillson NJ, Hu P, Andersen GL, Shapiro L RL Appl Environ Microbiol. 2007 Dec;73(23):7615-21.