HMM Summary Page: TIGR04432

Function23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr
Gene Symbolcfr
Trusted Cutoff550.00
Domain Trusted Cutoff550.00
Noise Cutoff450.00
Domain Noise Cutoff450.00
Isology Typeequivalog
EC Number2.1.1.224
HMM Length341
AuthorHaft DH
Entry DateApr 17 2013 3:03PM
Last ModifiedApr 17 2013 3:03PM
CommentThis model identifies Cfr, a 23S rRNA methyltransferase, EC, responsible for a transmissible form of chloramphenicol/florfenicol resistance. It is closely related to RlmN (see TIGR00048), an adenine C2-methyltransferase that acts at the same site where Cfr acts as a C8-methyltransferase
ReferencesRN [1] RM PMID:16091044 RT A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. RA Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B RL Mol Microbiol. 2005 Aug;57(4):1064-73. RN [2] RM PMID:16801432 RT The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. RA Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B RL Antimicrob Agents Chemother. 2006 Jul;50(7):2500-5.