HMM Summary Page: TIGR04432
| Accession | TIGR04432 |
| Name | rSAM_Cfr |
| Function | 23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr |
| Gene Symbol | cfr |
| Trusted Cutoff | 550.00 |
| Domain Trusted Cutoff | 550.00 |
| Noise Cutoff | 450.00 |
| Domain Noise Cutoff | 450.00 |
| Isology Type | equivalog |
| EC Number | 2.1.1.224 |
| HMM Length | 341 |
| Author | Haft DH |
| Entry Date | Apr 17 2013 3:03PM |
| Last Modified | Apr 17 2013 3:03PM |
| Comment | This model identifies Cfr, a 23S rRNA methyltransferase, EC 2.1.1.224, responsible for a transmissible form of chloramphenicol/florfenicol resistance. It is closely related to RlmN (see TIGR00048), an adenine C2-methyltransferase that acts at the same site where Cfr acts as a C8-methyltransferase |
| References | RN [1] RM PMID:16091044 RT A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. RA Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B RL Mol Microbiol. 2005 Aug;57(4):1064-73. RN [2] RM PMID:16801432 RT The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. RA Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B RL Antimicrob Agents Chemother. 2006 Jul;50(7):2500-5. |