HMM Summary Page: TIGR04431

Functionaminoglycoside N(6')-acetyltransferase, AacA4 family
Gene SymbolaacA4
Trusted Cutoff260.00
Domain Trusted Cutoff260.00
Noise Cutoff235.00
Domain Noise Cutoff235.00
Isology Typeequivalog
EC Number2.3.1.82
HMM Length184
AuthorHaft DH
Entry DateApr 6 2013 4:11PM
Last ModifiedApr 6 2013 4:11PM
CommentMembers of this family are the aacA4 type of aminoglycoside N(6')-acetyltransferase (EC, an enzyme that modifies and inactivates aminoglycoside antibiotics such as kanamycin, neomycin, tobramycin, and amikacin. Members are regularly spread among pathogens into integron, transposon, and plasmid loci, with recombination often happening within the protein-coding region. Most of the region amino-terminal to the recombination site or sites was removed from this model.
ReferencesRN [1] RM PMID:2841303 RT Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae. RA Nobuta K, Tolmasky ME, Crosa LM, Crosa JH RL J Bacteriol. 1988 Aug;170(8):3769-73.