HMM Summary Page: TIGR04430

Functionouter membrane lipid asymmetry maintenance protein MlaD
Gene SymbolmlaD
Trusted Cutoff135.00
Domain Trusted Cutoff135.00
Noise Cutoff120.00
Domain Noise Cutoff120.00
Isology Typeequivalog
HMM Length146
AuthorHaft DH
Entry DateApr 4 2013 3:46PM
Last ModifiedApr 4 2013 3:46PM
CommentMembers of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier.
ReferencesRN [1] RM PMID:19383799 RT An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. RA Malinverni JC, Silhavy TJ RL Proc Natl Acad Sci U S A. 2009 May 12;106(19):8009-14.