| Accession | TIGR04430 |
| Name | OM_asym_MlaD |
| Function | outer membrane lipid asymmetry maintenance protein MlaD |
| Gene Symbol | mlaD |
| Trusted Cutoff | 135.00 |
| Domain Trusted Cutoff | 135.00 |
| Noise Cutoff | 120.00 |
| Domain Noise Cutoff | 120.00 |
| Isology Type | equivalog |
| HMM Length | 146 |
| Author | Haft DH |
| Entry Date | Apr 4 2013 3:46PM |
| Last Modified | Apr 4 2013 3:46PM |
| Comment | Members of this protein family are the MlaD (maintenance of Lipid Asymmetry D) protein of an ABC transport system that seems to remove phospholipid from the outer leaflet of the Gram-negative bacterial outer membrane (OM), leaving only lipopolysaccharide in the outer leaflet. The Mla locus has long been associated with toluene tolerance, consistent with the proposed role in retrograde transport of phospholipid and therefore with maintaining the integrity of the OM as a protective barrier. |
| References | RN [1]
RM PMID:19383799
RT An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane.
RA Malinverni JC, Silhavy TJ
RL Proc Natl Acad Sci U S A. 2009 May 12;106(19):8009-14. |
